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Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism

JCP The effect of pomegranate juice (PJ) or grapefruit juice (GFJ) on CYP3A activity was studied in vitro and in healthy human volunteers.

 Thus, pomegranate juice does not alter clearance of intravenous or oral midazolam, whereas grapefruit juice (GFJ)  impairs clearance and elevates plasma levels of oral  midazolam.

 J Clin Pharmacol March 2007 vol. 47