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Pomegranate extract induces ellagitannin metabolite formation

In this study twenty healthy participants consumed 1000 mg of pomegranate extract daily for four weeks.

RESEARCH TITLE: Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers

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COUNTRIES:  USA

CONDUCTED BY:  Center for Human Nutrition, David Geffen School of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA; Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA; Research, VA Medical Center West Los Angeles, Los Angeles, USA; Department of Statistics Core, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA

PUBLISHED ON: Food and Function

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RESEACH:

The health benefits of pomegranate consumption are attributed to ellagitannins and their metabolites, formed and absorbed in the intestine by the microbiota. In this study twenty healthy participants consumed 1000 mg of pomegranate extract daily for four weeks.

Based on urinary and fecal content of the pomegranate metabolite urolithin A (UA), we observed three distinct groups: (1) individuals with no baseline UA presence but induction of UA formation by pomegranate extract consumption (n = 9); (2) baseline UA formation which was enhanced by POM extract consumption (N = 5) and (3) no baseline UA production, which was not inducible (N = 6).

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Compared to baseline the phylum Actinobacteria was increased and Firmicutes decreased significantly in individuals forming UA (producers). Verrucomicrobia (Akkermansia muciniphila) was 33 and 47-fold higher in stool samples of UA producers compared to non-producers at baseline and after 4 weeks, respectively. In UA producers, the genera Butyrivibrio, Enterobacter, Escherichia, Lactobacillus, Prevotella, Serratia and Veillonella were increased and Collinselladecreased significantly at week 4 compared to baseline.

The consumption of pomegranate resulted in the formation of its metabolites in some but not all participants. Pomegranate extract consumption may induce health benefits secondary to changes in the microbiota.

YEAR: 2015

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