The results of our study provide clear evidence that Pomegranate fruit extract possesses antiskin-tumor-promoting effects in CD-1 mouse. Because Pomegranate fruit extract is capable of inhibiting conventional as well as novel biomarkers of TPA-induced tumor promotion, it may possess chemopreventive activity in a wide range of tumor models.
Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-κB pathways and inhibits skin tumorigenesis in CD-1 mice.
Chemoprevention has come of age as an effective cancer control modality; however, the search for novel agent (s) for the armamentarium of cancer chemoprevention continues. We argue that agents capable of intervening at more than one critical pathway in the carcinogenesis process will have greater advantage over other single-target agents. Pomegranate fruit extract (PFE) derived from the tree Punica granatum possesses strong antioxidant and antiinflammatory properties.
The results of our study provide clear evidence that Pomegranate fruit extract possesses antiskin-tumor-promoting effects in CD-1 mouse. Because Pomegranate fruit extract is capable of inhibiting conventional as well as novel biomarkers of TPA-induced tumor promotion, it may possess chemopreventive activity in a wide range of tumor models.
Thus, an in-depth study to define active agent(s) in pomegranate fruit.
International Journal of Cancer,