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Effects of pomegranate juice on blood pressure in hypertensive individuals

Pomegranate juice is rich in bioactive phytochemicals with antioxidant, and anti-inflammatory and cardioprotective functions. The present trial investigated the acute effects of Pomegranate juice consumption on blood pressure and markers of endothelial function.

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THE POMEGRANATE SECRET
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Consumption of  Pomegranate juice could be considered in the context of both dietary and pharmacological interventions for hypertension.

RESEACH TITLE: Clinical investigation of the acute effects of pomegranate juice on blood pressure and endothelial function in hypertensive individuals

 COUNTRY: Iran

CONDUCTED BY:  University of Medical Sciences, Iran.Professor, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran 

PUBLISHED ON:  Arya atherosclerosis

RESEACH:

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Background

Pomegranate juice is rich in bioactive phytochemicals with antioxidant, and anti-inflammatory and cardioprotective functions. The present trial investigated the acute effects of Pomegranate juice consumption on blood pressure and markers of endothelial function.

Methods

In this single-arm study, thirteen hypertensive men aged 39-68 years were recruited. Included subjects were assigned to natural Pomegranate juice (150 ml/day) following a 12 hour fast. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and flow-mediated dilation (FMD), along with serum concentrations of C-reactive protein (CRP), intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin and interleukin-6 (IL-6) were measured at baseline and 4-6 hours after Pomegranate juice consumption.

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Results

Comparison of pre- vs. post-trial values revealed a significant reduction in both SBP (7%; P = 0.013) and DBP (6%; P < 0.010). However, changes in FMD (20%) as well as circulating levels of CRP, ICAM-1, VCAM-1, E-selectin, and IL-6 did not reach statistical significance (P = 0.172).

Conclusion

Pomegranate juice has promising acute hypotensive properties. Consumption of  Pomegranate juice could be considered in the context of both dietary and pharmacological interventions for hypertension.

 YEAR: 2013

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