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Pomegranate juice improves behavior in a mouse model of Alzheimer’s disease

These results suggest that further studies to validate and determine the mechanism of these effects, as well as whether substances in pomegranate juice may be useful in AD, should be considered.

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THE POMEGRANATE SECRET
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Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer’s disease.

Although there are no proven ways to delay onset or slow progression of Alzheimer’s disease (AD), studies suggest that diet can affect risk. Pomegranates contain very high levels of antioxidant polyphenolic substances as compared to other fruits and vegetables. Polyphenols have been shown to be neuroprotective in different model systems.

Mice treated with pomegranate juice had significantly less (∼ 50%) accumulation of soluble Aβ42 and amyloid deposition in the hippocampus as compared to control mice. These results suggest that further studies to validate and determine the mechanism of these effects, as well as whether substances in pomegranate juice may be useful in AD, should be considered.

Neurobiology of Disease, volume 24, Issue 3, 

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