Pomegranate juice (PJ) was shown to inhibit macrophage foam cell formation and development of atherosclerotic lesions. The aim of this study was to elucidate possible mechanisms by which Pomegranate juice reduces cholesterol accumulation in macrophages.
We conclude that Pomegranate juice mediated suppression of Ox-LDL degradation and of cholesterol biosynthesis in macrophages can lead to reduced cellular cholesterol accumulation and foam cell formation.
Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages
the Journal of Nutritional Biochemistry, Volume 16, Issue 9, September 2005