Skip to content

Protective effects of hydroxytyrosol in rheumatoid arthritis

Hydroxytyrosol, a typical virgin olive oil phenolic compound, has beneficial antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the effect of hydroxytyrosol-supplemented refined olive oil at 0.5 and 5 mg/kg in a rodent model of rheumatoid arthritis.

Hydroxytyrosol-from-extra-virgin-olive-oil
Slide
hidroxitirosol-eng
Hydroxytyrosol-from-extra-virgin-olive-oil
previous arrow
next arrow

RESEARCH TITLE: Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis

COUNTRIES: Portugal

CONDUCTED BY: Faculdade de Farmacia de Universidade de Lisboa, Portugal; IMED Reseach Institute for Medicines, Lisboa, Portugal

PUBLISHED ON: The Journal of Nutritional Biochemistry

RESEARCH:

Abstract

THE POMEGRANATE SECRET
punicalagin
THE POMEGRANATE SECRET
punicalagin
previous arrow
next arrow

Virgin olive oil is the primary source of fat in the Mediterranean diet, and its beneficial health effects have been related with oleic acid and phenolic compounds content.

Hydroxytyrosol, a typical virgin olive oil phenolic compound, has beneficial antioxidant and anti-inflammatory properties as previously reported. The aim of this study was to evaluate the effect of hydroxytyrosol-supplemented refined olive oil at 0.5 and 5 mg/kg in a rodent model of rheumatoid arthritis. Rheumatoid arthritis was induced by intradermic administration, in male Wistar rats, of Freund’s adjuvant with collagen type II on days 1 and 21. Hydroxytyrosol-supplemented refined olive oils were administrated by gavage from day 23 until day 35. The treatment at 5-mg/kg dose significantly decreased paw edema (P<.01), histological damage, cyclooxygenase-2 and inducible nitric oxide synthase expression, and markedly reduced the degree of bone resorption, soft tissue swelling and osteophyte formation, improving articular function in treated animals. Acute inflammation, induced by carrageenan, was also evaluated for hydroxytyrosol-supplemented refined olive oils at 0.5 and 5 mg/kg. Both doses significantly reduced paw edema (P<.001). Our results suggest that the supplementation of refined olive oil with hydroxytyrosol may be advantageous in rheumatoid arthritis with significant impact not only on chronic inflammation but also on acute inflammatory processes.

YEAR: 2014

Hydroxytyrosol-from-extra-virgin-olive-oil
hidroxitirosol-eng
THE POMEGRANATE SECRET
punicalagin
THE POMEGRANATE SECRET
previous arrow
next arrow