Antioxidant activity of hydroxytyrosol reduces the inflammation in children with pediatric non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children in developed countries. This high prevalence is due to the close relationship with childhood obesity, a pathology with an epidemic category. Several studies have shown that oxidative stress and liver inflammation are responsible for the progression of this illness. On the other hand, hydroxytyrosol, which is found in the olive tree and extra virgin olive oil, has been investigated as an antioxidant and anti-inflammation agent in the last few years.
Recently, Antonella Mosca and co-workers at the Bambino GesùChildren’s Hospital in Italy, have studied if the combination of Vitamin E and hydroxytyrosol could reduce liver inflammation and oxidative stress in children. They found that this treatment, after four months, was able to improve inflammation by changing the levels of several parameters that are sensitive to the bioactive compounds included in the pharmacological product. This study is the first evidence that the treatment with hydroxytyrosol and Vitamine E reduces the abnormal accumulation of triglycerides in pediatric NAFLD by improving systemic inflammation and oxidative stress.
Article: Antioxidant activity of Hydroxytyrosol and Vitamin E reduces systemic inflammation in children with paediatric NAFLD. https://doi.org/10.1016/j.dld.2020.09.021