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POMEGRANATE “5 targets against SARS-CoV-2 Covid-19”


Pomegranate can become a weapon against SARS-CoV-2 covid-19 according to the results provided by these 5 researches.


    First target, its potential inhibitory activity of SARS-CoV-2 Covid-19

    Carried out at the Banja Luka University of Bosnia Herzegovina and published in Molecular and Cellular Biochemistry.

    The researchers highlight the potential inhibitory activity of polyphenols in pomegranate extract against the internalization process of SARS-CoV-2.

    Furthermore, the presented molecular coupling study demonstrated that the components of pomegranate extract, that such as punicalagin and punicalin, are promising candidates for new anti-SARS-CoV-2 in vitro studies.

    There are currently no medications proven to be effective for the prevention or treatment of the SARS-CoV-2 infection, and researchers are desperately trying to discover molecules with efficient antiviral activity. Including natural products from herbal medicine. One of those is pomegranate.

    Being ingredients of a natural product which are used as food, these candidates have also a confirmed safety profile which is their additional and important advantage in the treatment of the disease.

    Second target, the ability to inhibit the activity of various SARS-CoV-2 Covid-19 proteins.

    Carried out at the University of Naples and published in biorxiv. The results open up new and promising opportunities to use natural pomegranate extracts for the development of effective and innovative therapies in the fight against SARS-CoV-2. Pomegranate extract (among other plant extracts are rich in bioactive compounds) may play key roles in preventing and counteracting the rapid spread of SARS-CoV-2 infections, by inhibiting the activity of several viral proteins in particular those involved in the virus entry into the host cells and its replication.

    Third target, successful inhibition of the COVID-19 protease enzyme

    This research carried out at the Faculty of Agriculture of the University of Benha discovered that the hydrolysable tannins of the pomegranate extract interact faithfully with the receptor binding site and the catalytic dyad (Cys145 and His41) of the main viral protease, showing their successful inhibition of the COVID-19 protease enzyme.

    Fourth target, to strengthen the immune response to Covid-19

    Carried out at the Sam Higginbottom University of Hygiene and Technology. The results reinforce the hypothesis that pomegranate polyphenols can inhibit the virus’s protease in combination with other therapies to to strengthen immune system response, it could provide an effective therapeutic regimen for fight against all diseases associated with COVID-19 and improve the resistance to fight the virus in early stages of human infection.

    Fifth target, prevention and control of the spread Covid-19

    Carried out by the University of Pescara and carried out in humans who are carriers of COVID-19 but asymptomatic. It provides us with new studies on the evolution of COVID-19 in patients, for the moment, unpredictable with this model, but virucidal products such as pomegranate extract can assume significant community value in preventing and controlling the spread.

    A lower viral load can mean a lower level of spread of COVID-19

    If you want to know more about the pomegranate you have a free reading through three books made by the Miguel Hernández University about Pomegranate Grown in Spain, its compounds, processed products and its health properties.

    Pomegranate Grown in Spain “Antioxidant punicalagin from pomegranate juice and pomegranate extract in the functional diet of the future” Year 2010
    Free download

    Pomegranate “Bioactive Punicalagins and Urolithins with beneficial properties for health” Year 2020
    Free download

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