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Potential inhibitory activity of Punicalagina against SARS-CoV-2


The punicalagin of pomegranate exhibited very promising potential to inhibit the entry of SARS-CoV-2 into our cells by interactions with protein targets with a significant role in this process.

Since its flare-up, the coronavirus disease SARS-CoV-2 (COVID-19) has affected our quality of life and cost hundreds-of-thousands of lives globally. Due to its world-wide spread and mortality, there is an urgent search for novel therapies which can combat this disease.

Recently, in the Faculty of Medicine of University of Banja Luka in Bosnia and Herzegovina, Relja Suručić and co-workers have been studied the binding affinities and interactions of punicalagin with four selected protein targets with a significant role in the process of the entry of SARS-CoV-2 virus into our cells.

The results of this theoretical study showed that this constituent of pomegranate exhibited significant interactions with the selected proteins and therefore, possessed very promising potential to inhibit the entry of the virus into the cell.

RESEARCH TITLE: Computational study of pomegranate peel extract polyphenols as potential inhibitors of SARS-CoV-2 virus internalization. Molecular and Cellular Biochemistry

COUNTRIES: Bosnia and Herzegovina

CONDUCTED BY: Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina

PUBLISHED ON: Molecular and Cellular Biochemistry

YEAR: 2021