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Punicalagin could be a potent drug for rheumatoid arthritis therapy

A recent study reveals that punicalagin, the most enriched polyphenols in pomegranate, could prevent and treat rheumatoid arthritis.

Arthritis is a chronic autoimmune disease that occurs when the immune system mistakenly attacks the body’s tissues. This disorder affects the lining of the joints and causes painful swelling that can eventually cause bone destruction and joint deformity. The inflammation associated with rheumatoid arthritis is what can damage other parts of the body as well. While new drugs have greatly improved treatment options, severe rheumatoid arthritis can still cause physical disabilities.

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Punicalagin is the most enriched polyphenols in pomegranate and has been investigated as an antioxidant, anti-inflammatory, and anti-cancer agent. In addition, many studies suggest punicalagin are potentially helpful in the treatments of chronic inflammatory diseases and tumors.

Recently, Mingcheng Huang and co-workers in the Seventh Affiliated Hospital of Sun Yat-Sen University have investigated the effects of punicalagin on synovial inflammation and bone destruction in arthritis.

Their study provided new in vivo and in vitro evidence for the anti-arthritis effects of punicalagin in arthritis. They identified the inhibitory impact of punicalagin in inflammation and checked that this compound alleviated arthritis severity and bone destruction.

These results indicate that punicalagin could be used as a natural therapeutic compound to prevent and treat rheumatoid arthritis.

Article: Punicalagin Inhibited Inflammation and Migration of Fibroblast-Like Synoviocytes Through NF-κB Pathway in the Experimental Study of Rheumatoid Arthritis. https://doi.org/10.2147/JIR.S302929

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