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Antifungal activity of pomegranate against dermatophytes

Dermatophyte species infect the epidermis and appendages, often with serious social and health-economic consequences. The hydroalcoholic extract of pomegranate fruit peel showed activity against the dermatophyte fungi Trichophyton mentagrophytes, T. rubrum, Microsporum canis and M. Gypseum.

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These results indicated that the crude extract and punicalagin had a greater antifungal activity against T. rubrum, indicating that the pomegranate is a good target for study to obtain a new antidermatophyte medicine.

RESEACH TITLE:  Antifungal activity of pomegranate peel extract and isolated compound punicalagin against dermatophytes

COUNTRY: Brazil

CONDUCTED BY: Universidade Estadual de Londrina and Maringá, Brazil

PUBLISHED ON: Annals of Clinical Microbiology and Antimicrobials

RESEACH:

Background

Dermatophyte species infect the epidermis and appendages, often with serious social and health-economic consequences. The hydroalcoholic extract of pomegranate fruit peel showed activity against the dermatophyte fungi Trichophyton mentagrophytes, T. rubrum, Microsporum canis andM. gypseum.

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Methods

Hydroalcoholic extract was prepared with pomegranate peels. This crude extract was fractionated and submitted to liquid-liquid partition, resulting in an active fraction which was fractionated in a Sephadex LH-20 column, followed by a Lobar column. The structure of the active compound was established with the use of spectroscopic methods.

Results

The crude extract of pomegranate fruit peel showed activity against the dermatophytesTrichophyton mentagrophytes, T. rubrum, Microsporum canis, and M. gypseum, with MICs values of 125 ?g/ml and 250 ?g/ml, respectively for each genus. Punicalagin was isolated and identified by spectroscopic analysis. The crude extract and punicalagin showed activity against the conidial and hyphal stages of the fungi. The cytotoxicity assay showed selectivity for fungal cells than for mammalian cells.

Conclusions

These results indicated that the crude extract and punicalagin had a greater antifungal activity against T. rubrum, indicating that the pomegranate is a good target for study to obtain a new antidermatophyte medicine.

YEAR: 2014

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