This study was aimed to investigate the role of pomegranate seed oil (PSO) as antioxidant in alleviating the deleterious effects of methionine overload in some biochemical aspects of adult female rabbits.
The study conclude that methionine overload induced oxidative stress and pomegranate seed oil can ameliorate the oxidative stress evidenced by measured biomarkers.
RESEARCH TITLE: The Protective Effect of Pometone (Pomegranate Seed Oil) on Oxidants /Antioxidant Status in Methionine Overload Rabbits
COUNTRIES: Iraq
CONDUCTED BY: Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Baghdad-Iraq
PUBLISHED ON: Nexus Academic Publishers
RESEACH:
This study was aimed to investigate the role of pomegranate seed oil (PSO) as antioxidant in alleviating the deleterious effects of methionine overload in some biochemical aspects of adult female rabbits.
Thirty two female rabbits were randomly assigned into four equal groups and given orally the following treatment for 42 days: the first groups was drenched corn oil, serving as control group (C), the second group (T1 ) was intubated with methionine 100mg/kg. B.W, the third groups (T2 ) was intubated with methionine 100mg/kg. B.W and pomegranate seed oil (PSO) 30 mg /Kg. B.W., while animals in the group T3 were intubated with pomegranate seed oil 30 mg/Kg. B.W.
Fasting blood samples were collected at 0, 21 and 42 days of experiment to assess: serum total cholesterol(TC), malondialdehyde (MDA), peroxynitrite radicals, reduced glutathione (GSH) concentrations and lactate dehydrogenase activity( LDH). At the end of the current study group T1 showed a significant increase in TC, MDA, peroxynitrite radicals concentrations and LDH activity with significant reduction in GSH concentration.
Besides the results showed a significant decrease in serum TC and peroxynitrite radical concentrations with significant elevation in GSH concentration in group T3 as compared with the control. It can be concluded that intubation of pomegranate seed oil correct the oxidative stress in methionine overload rats.
The study conclude that methionine overload induced oxidative stress and pomegranate seed oil can ameliorate the oxidative stress evidenced by measured biomarkers.
YEAR: 2015