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Antioxidative Wirkung von Hydroxytyrosol Skip to content Verschiedene wissenschaftliche Untersuchungen bestätigen die positive Wirkung von Hydroxytyrosol. Die Freie Universität Katalonien (Universitat Oberta de Catalunya) veröffentlichte im Jahr 2015: „Hydroxytyrosol, das beste natürliche Antioxidans und zugleich das unbekannteste.“ Eine vergleichende Studie mit anderen Antioxidanzien zeigte, dass Hydroxytyrosol möglicherweise das beste natürliche Antioxidans ist, bis heute sind noch nicht alle Wirkungen vollständig erforscht. Aus diesem Grund werden nachfolgend eine Reihe von Schlussfolgerungen beschrieben.
Antioxidative Wirkung von Hydroxytyrosol In verschiedenen in vitro durchgeführten Tests wurde festgestellt, dass Hydroxytyrosol einen höheren Schutz vor verschiedenen Radikalen wie den Mizellen der Linolsäure oder bei der Eliminierung des Superoxidanions bietet als Oleuropein und Vitamin E. Ebenfalls nachgewiesen wurde seine antioxidative Wirksamkeit gegen Hypochloritschäden. Kurz gesagt, die große antioxidative Kapazität von Hydroxytyrosol, die in mehreren In-vitro-Studien nachgewiesen wurde, liegt über den Werten der Vitamine C und E.
Hydroxytyrosol ist eine Substanz, die auf natürliche Weise im menschlichen Körper vorhanden ist, sodass die vom Organismus als natürlich erkannten Phenole des Olivenbaums frei zirkulieren können, ohne die Anpassungsprobleme anderer Arten körperfremder Polyphenole zu verursachen. Ebenso wenig entstehen Probleme durch die Anhäufung von Polyphenolen im Organismus, da sie wasserlöslich sind und vom Nieren- und Verdauungssystem ausgeschieden werden.
Antisklerotische Aktivität von Hydroxytyrosol Mehrere Studien deuten darauf hin, dass die Lipoproteinperoxidation für die Entstehung von Arteriosklerose verantwortlich ist. Die Peroxidation modifiziert LDL und bildet Fettablagerungen, die Atherome produzieren. In-vitro-Studien zeigten, dass Ratten, die eine olivenölreiche Ernährung erhielten, eine größere Resistenz gegen Lipidperoxidation aufwiesen als Ratten, die eine andere Ernährung erhielten.
In anderen Tier- und Humanstudien wurde festgestellt, dass polymorphnukleäre Leukozyten an der Entstehung von koronaren Herzkrankheiten, Angina und anderen Folgen der Arteriosklerose beteiligt sind. Mit Hilfe von Messungen wurde nachgewiesen, dass das verantwortliche Enzym die 5-Lipoxygenase ist, die durch die phenolischen Verbindungen des Olivenöls mit großer Wirksamkeit gehemmt wird.
Antimikrobielle Wirkung von Hydroxytyrosol Hydroxytyrosol hat sich bei klinisch isolierten Stämmen als antimikrobielles Mittel gegen pathogene Bakterien beim Menschen erwiesen, das eine höhere Wirksamkeit zeigt als Erythromycin und Ampicillin. Einige dieser Pathogene sind Haemophilus influenzae, Salmonella spp. und Vibrio parahaemolyticus.
Apoptose induzierende Kapazität von Hydroxytyrosol Die Chemoprävention ist derzeit eine der wichtigsten Krebsbehandlungen. Antioxidanzien zeigen in diesem Bereich eine vielversprechende Prognose. Epidemiologische Studien haben gezeigt, dass Natives Olivenöl Extra eine präventive Wirkung auf Brust- und Darmkrebs hat.
Gesundheitliche Vorteile von Hydroxytyrosol: Schutz des Herz-Kreislauf-Systems Verschiedene In-vitro- und In-vivo-Studien kommen zu dem Schluss, dass Hydroxytyrosol das LDL vor Oxidation durch freie Radikale schützt. Es reduziert außerdem die Produktion von Molekülen, die am Endothel haften. Durch den Konsum von Hydroxytyrosol in signifikanten Mengen kann man Glutathion regulieren und das Fettgewebe mit antioxidativen Enzymen versorgen. Die EFSA (European Food and Safety Authority) bestätigte 2012, dass Hydroxytyrosol LDL vor der Oxidation durch freie Radikale schützt und einer Gefäßverschlechterung durch Arteriosklerose vorbeugt.
Schutz gegen neurodegenerative Prozesse Verschiedene Studien deuten darauf hin, dass der Konsum von Polyphenolen das Risiko einer Neurodegeneration und eines kognitiven Verfalls im Zusammenhang mit dem Alter reduziert. Das Gehirn benötigt für seine Aktivität viel Energie, weil es viel Sauerstoff verbraucht. Während des oxidativen Prozesses wird eine große Menge an freien Radikalen erzeugt, die die Zellen schädigen. Hydroxytyrosol kann Gehirnzellen vor Lipidperoxidation schützen, da es in der Lage ist, die Blut-Hirn-Schranke zu überschreiten.
Schutz gegen Krebs Studien über den Konsum von Nativem Olivenöl Extra und die Verbreitung von Krankheiten in der Bevölkerung weisen auf ein geringeres Vorkommen von Brustkrebs hin. Hydroxytyrosol schützt vor der Vermehrung von Krebszellen und der Apoptose in Milchepithelzellen oder Krebszellen.
Hydroxytyrosol beugt oxidativen DNA-Schäden vor Entzündungshemmend Bei Entzündungen entstehen freie Radikale und Antioxidanzien werden reduziert. Hydroxytyrosol hat die Fähigkeit, die COX- und LOX-Enzyme der Arachidonsäure (AA) zu hemmen und reduziert so den für Entzündungen typischen oxidativen Abbau.
Muskel- und Gelenkschutz Hydroxytyrosol regt die Produktion von Chondrozyten an, die den Gelenkknorpel regenerieren und reparieren. Hydroxytyrosol hilft auch bei körperlicher Anstrengung, da es die Produktion von Glutathion (endogenes Antioxidans) erhöht und die Produktion von Milchsäure und damit die Muskelatrophie verringert.
Schutz gegen AIDS Hydroxytyrosol bildet zusammen mit Oleuropein die erste Gruppe von Molekülen, die mehrere Wirkungen gegen das AIDS-Virus entfalten können. Hydroxytyrosol hemmt den Eintritt und die Integration von Viren. Es wirkt inner- und außerhalb der Zellen. Dieser Sachverhalt ist ein guter Ausgangspunkt für die Entwicklung neuer HIV-Hemmer.
Schutz des Immunsystems Durch Unterdrückung der LDL-Synthese beugt Hydroxytyrosol Darm- und Brustkrebs, dem prämenstruellen Syndrom und Herz-Kreislauf-Erkrankungen vor. Es hat außerdem eine antimikrobielle Wirkung und zerstört Kolonien von Mikroorganismen, die Infektionen der Atemwege, des Darms und der Genitalien verursachen.
Vorbeugung von Osteoporose Die Verabreichung von Hydroxytyrosol hat positive Auswirkungen auf die Knochenbildung und das Knochenwachstum, daher kann man die Symptome der Osteoporose mit Hydroxytyrosol behandeln.
Hydroxytyrosol zum Schutz vor anderen Krankheiten: Schutz der Retina Hydroxytyrosol ist vorteilhaft für die Gesundheit der Augen, insbesondere bei der Regeneration des retinalen Pigmentepithels, bei Makuladegeneration und bei Glaukom durch oxidativen Stress.
In der wässrigen Fettphase wirkt es dermoprotektiv Es schützt vor UVB-Strahlen. Es verringert die Pigmentierung der Haut. Es schützt vor Ödemen und Erythemen, die durch übermäßige Sonneneinstrahlung verursacht werden. Es kann sogar bei der Bekämpfung der Psoriasis wirksam sein.
Anti-Ageing-Effekt Es stimuliert die Produktion von Proteinen, die das Zellüberleben fördern.
Deutliche Zunahme der Forschung zur Bestimmung der gesundheitsfördernden Eigenschaften von Hydroxytyrosol Es besteht kein Zweifel am Engagement von Forschern auf der ganzen Welt, die gesunden Eigenschaften dieses Polyphenols auszuwerten. Nachfolgend finden Sie einige der neuesten Studien und Links, um mehr über diese Untersuchungen zu erfahren.
Kürzlich veröffentlichte Eigenschaften von Hydroxytyrosol Literaturhinweise de la Fuente, P. et al. ’Propiedades antioxidantes del Hidroxitirosol procedente de la hoja del olivo (Olea europaea L) ’ ‘Los fenoles del aceite de oliva’ . EFSA.González Santiago, M.P. ‘Estudio de los efectos cardiovasculares y la absorción oral del hidroxitirosol en modelos animales y humanos’ . Universidad de Granada. 2005. Tesis doctoral. Shaffer, S. et al. ‘Cytoprotective effects of olive mill wastewater extract and its main constituent hydroxytyrosol in PC12 cells’’ . Elsevier. 2010. Publicado por: Pharmacol Res. 62(4):322-7. Silva, S. et al. ‘Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis’ . PubMed. US National Library of Medicine. National Institute of Health. 2015. Publicado por: J.Nutr Biochem. 26 (4): 360-8. Warleta, F. et al. ‘Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells.’ Nutrients. 2011. National Library of Medicine. 2011. Publicado por: Nutrients. 3(10):839–857. Lee-Huang, S. et al. ‘Discovery of Small-Molecule HIV Fusion and Integrase Inhibitors Oleuropein and Hydroxytyrosol : II. Integrase Inhibition’. US National Library of Medicine. Institutes of Health. 2007. Publicado por: Biochem Biophys Res Commun. 354(4):879– 884. Fistonic, I. et al. ‘Olive oil biophenols and women’s health’ . US National Library of Medicine. National Institutes of Health. 2012. Publicado por: Med Glas (Zenica). 9(1) 1- 9. Cabrerizo S, De La Cruz JP, López-Villodres JA, Muñoz-Marín J, Guerrero A, Reyes JJ, Labajos MT, González-Correa JA. Role of the inhibition of oxidative stress and inflammatory mediators in the neuroprotective effects of hydroxytyrosol in rat brain slices subjected to hypoxia reoxygenation .JNutrBiochem.2013;24:2152-2157. 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Nutr Rev. 2010; 68: 191-206. Guerrero A, De la Cruz JP, Muñoz-Marín J, López-Villodres JA, Madrona A, Espartero JL, González-Correa JA. Neuroprotective effect of alkyl hydroxytyrosyl ethers in rat brain slices subjected to a hypoxia-reoxygenation model . Food Chemistry.2012; 134(4): 2176–2183. Hamden K, Allouche N, Damak M, Elfeki A. Hypoglycemic and antioxidant effects of phenolic extracts and purified hydroxytyrosol from olive mill waste in vitro and in rats . Chemico-Biological Interactions. 2009; 180(3): 421–432. Jemai H, Bouaziz M, Fki I, El Feki A, Sayadi S. Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves . Chemico-Biological Interactions. 2008; 176(2-3): 88–98. Jemai H, El Feki A, Sayadi S. Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein from olive leaves in alloxan-diabetic rats . Journal of Agricultural and Food Chemistry. 2009; 57(19): 8798–8804. 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Reyes JJ, Villanueva B, López-Villodres JA, De La Cruz JP, Romero L, RodríguezPérez MD, Rodríguez-Gutiérrez G, Fernández-Bolaños J, González-Correa JA. Neuroprotective Effect of hydroxytyrosol In Experimental Diabetes Mellitus . J Agric Food Chem. 2016.DOI: 10.1021/acs.jafc.6b02945. Richard N, Arnold S, Hoeller U, Kilpert C, Wertz K, Schwager J. Hydroxytyrosol is the major anti-inflammatory compound in aqueous olive extracts and impairs cytokine and chemokine production in macrophages . Planta Med. 2011;77:1890-1897. Rietjens SJ, Bast A, de Vente J, Haenen GR. The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress-induced impairment of the NObullet response of isolated rat aorta. Am J Physiol Heart Circ Physiol. 2007; 292:H1931-1936. Rodríguez-Morató J, Xicota L, Fitó M, Farré M, Dierssen M, de la Torre R. Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases . 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Hydroxytyrosol excretion differs between rats and humans and depends on the vehicle of administration . The Journal of Nutrition. 2006; 133(8): 2612–2615. Vissers MN, Zock PL, Katan MB. Bioavailability and antioxidant effects of olive oil phenols in humans: a review. European Journal of Clinical Nutrition. 2004; 58(6):955–965. Waterman E, Lockwood B. Active components and clinical applications of olive oil. Alternative Medicine Review: A Journal of Clinical Therapeutic. 2007; 12(4): 331–342. Zhang X, Cao J, Zhong L. Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells. NaunynSchmiedebergs Arch Pharmacol.2009; 379: 581-586. Zhong YW, Wu J, Hu HL, Li WX, Zhong Y.Protective effect 3,4- dihydroxyphenylethanol in subarachnoid hemorrhage provoked oxidative neuropathy. ExpTher Med. 2016;12:1908-1914. Zhu L, Liu Z, Feng Z, Hao J, Shen W, Li X, Sun L, Sharman E, Wang Y, Wertz K, Weber P, Shi X, Liu J. 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